![]() Reconstructed the SMA image of MPR, MIP, VR, showed pathological changes of SMA in best angle. ![]() constrast medium was ultravist (300 mgI/L) 80-90 ml, flow rate was 3.5 ml/s. To use 16 slices CT, detector 1.25 mm X 8, reconstruction interval 1.0 mm, reconstruction slice thickness 1.3 mm. Methods: Forty-five cases patients, suspected SMA lesion, male 30 cases, female 15 cases, average 50 years. Objective: To analyze retrospectively MSCT angioimage of superior mesenteric artery (SMA) lesion, study the clinical application and value of MSCT angioimage of SMA. The unique features of SMA-ZnPP micelles are that they are nanoparticles in aqueous solution having high water solubility and loading, yet macromolecular in nature, which can be beneficial in targeted release of a potent HO-1 inhibitor. SMA-ZnPP micelles inhibited splenic microsomal HO-1 activity, in a competitive and dose-dependent manner, with an apparent inhibitory constant (K(i)) of 0.12mum, comparable to free ZnPP and also exhibited marked cytotoxic effect on KYSE-510 human esophageal cancer cells. The micelles showed a constant ZnPP release rate of about 0.5%/day in vitro at neutral pH. SMA-ZnPP had an average molecular size of 144kDa as determined by size-exclusion chromatography (SEC), this size is a marked increase from the molecular weight of free ZnPP (626.03Da), suggesting the formation of micellar structure. having tunable loading (from 15% to 60% w/w of ZnPP) with remarkable aqueous solubility. ![]() ![]() The micelles (SMA-ZnPP) thus formed were nanoparticles with narrow size distribution in water (mean diameter 176.5nm). The micelles were constructed by subtle pH adjustments to form non-covalent interaction between the hydrophobic ZnPP and amphiphilic SMA. Amphiphilic styrene-maleic acid (SMA) copolymer efficiently formed micelles with a potent heme oxygenase inhibitor-zinc protoporphyrin (ZnPP). ![]()
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